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? 負責3個跨機構科研合作項目的管理工作，合作方為香港中文大學。共管理資金500萬港幣，并通過起草和執行資金管理策略，包括與銷售人員制定銷售協議，為兩機構共節省20萬元港幣。管理過程中，按時以PPT和郵件方式向實驗室負責人和合作伙伴匯報進程，并和合作方管理人員保持緊密聯系以確保項目的順利進行以及項目目標的完成。 ? 管理3組由2到4名本科和博士生組成的研究團隊，負責溝通解決項目進行中出現的人事糾紛和技術性問題，并對科研問題給予專業指導。修改4篇由作者擬好的英文學術文章并輔助文章在國際期刊的順利發表。 ? 管理科研數據。 Managed 3 cross-organizational projects with total government grants worth of HK$5 million ? Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction ? Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations ? Monitored progress and ensured projects meet deadlines in a timely and accurate fashion ? Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved ? Negotiated with venders and achieved business agreements ? Provided regular updates on progress to lab director and collaborators through data presentations and written reports ? Provided expertise on study design and research methodology ? Troubleshooted experimental and technical problems ? Managed and securely stored data ? Reviewed 4 articles intended for publication in internally recognized journals ? 建立兩個可以用于商業化的 CRISPR-Cas9 基因敲除穩定細胞系。 ? 建立了3個新型激酶在人體內的作用對象的數據庫，并完善了利用概率來篩選和分析蛋白分子互動對象的數學方法。 ? 設計并完成關于幾類新型激酶在卵巢癌和肝癌的發展和轉移中所起作用的研究，其中，明確確定了SBK1激酶在卵巢癌發展中的作用。研究中運用到生物細胞學、生物化學、蛋白學、統計學和動物模型等實驗方法。 ? 與學院內蛋白小分子、干細胞等實驗組以及香港中文大學某實驗室取得了合作，并帶領、輔導2支國外本科交流實習生隊伍參與與此課題相關的實驗。 ? 起草并提交實驗室科研經費申請。 Led a large-scale research project to investigate the activities of previously unknown kinases in ovarian and hepatic cancer ? Generated 2 CRISPR-Cas9 stable gene knockout cell lines available for commercial use ? Developed a probability-based algorithm to screen and analyze protein inter candidates ? Established kinase targets databases for 3 novel kinases ? Verified the mechanism of novel gene SBK1 in ovarian cancer metastasis ? Mentored 2 groups of international undergraduate interns ? Collaborated with teams in FHS and the Chinese University of Hong Kong ? Prepared and submitted proposals for grant applications in line with group strategies ? Executed a series of experiments on protein characterization, protein-protein inter and functional assays in vitro and in vivo

? 建立了與包括加拿大國家中子中心、 勞厄-朗之萬研究所（法國）、Helmholtz-Zentrum Berlin（HZB德國）、巴斯大學、拉塞福-阿普頓實驗室、格拉斯哥大學和羅斯林研究所（英國）在內的7所國際知名科研中心的學術合作，并多次獲得中子機構給予的科研經費。期間與10多個由多學科人員組成的當地團隊一起工作，與主要人員建立了長期合作關系。 ? 通過物理學和數據分析來研究艾滋海默癥病理。物理學采用包括光學、分子運動學和中子衍射等一系列物理學原理來學習該病病原淀粉樣蛋白的物理結構及結構變化，以及該蛋白在不同結構下對細胞磷脂層的作用；數學主要應用傅立葉變化將由中子衍射發出的信號轉變為磷脂分子模型，進而分析磷脂在淀粉樣蛋白作用下的變化。博士畢業論文：淀粉樣蛋白和磷脂細胞的相互作用關系。 ? 創立了體外控制淀粉樣蛋白聚集的方法。 ? 改進并完善了利用Langmuir膜和布魯斯特角顯微鏡來觀測磷脂單分子層在水與空氣交接面的狀態的方法。 Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics Thesis title: The inter between Amyloid beta peptide and lipid membranes ? Established collaborations with 7 world-renowned institutes including Canadian Neutron Beam Centre, The Institute Laue-Langevin, Helmholtz-Zentrum Berlin, University of Bath, Rutherford on Laboratory, University of Glasgow and the Roslin Institute ? Worked in 10+ multidisciplinary teams in Europe and Canada to identify the structural characteristics of amyloid protein and the biophysics of protein-lipid inters received neutron beam time al and traveling grants from neutron scattering facilities ? Performed mathematical analysis based on Fourier transform to generate membrane profile from neutron diffr data sets and predict protein penetration position ? Created a novel methodology to protein folding rate in non-physiological environments ? Improved Langmuir trough and Brewster Angle Microscopy techniques to monitor lipid mono dynamics at air-water interface

應用物理和數學方法學習阿茲海默癥病理/ Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics

獸醫病理學/ Veterinary Pathology 獸醫臨床/ Veterinary Surgery 生物/ Biology 有機化學/ Organic Chemistry

負責3個跨機構科研合作項目的管理工作，合作方為香港中文大學，共管理資金500萬港幣/ Managed 3 cross-organizational research projects with total government grants worth of HK$5 million

? 通過起草和執行資金管理策略，包括與銷售人員制定銷售協議，為兩機構共節省20萬元港幣。管理過程中，按時以PPT和郵件方式向實驗室負責人和合作伙伴匯報進程，并和合作方管理人員保持緊密聯系以確保項目的順利進行以及項目目標的完成。 ? 管理3組由2到4名本科和博士生組成的研究團隊，負責溝通解決項目進行中出現的人事糾紛和技術性問題，并對科研問題給予專業指導。修改4篇由作者擬好的英文學術文章并輔助文章在國際期刊的順利發表。 ? 管理科研數據。 ? Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction ? Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations ? Monitored progress and ensured projects meet deadlines in a timely and accurate fashion ? Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved ? Negotiated with venders and achieved business agreements ? Provided regular updates on progress to lab director and collaborators through data presentations and written reports ? Provided expertise on study design and research methodology ? Troubleshooted experimental and technical problems ? Managed and securely stored data ? Reviewed 4 articles intended for publication in internally recognized journals